2 Hypothesis

1. Feb 4th, 2016 They propose that normal tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing. (Science Today)
2. Restated Boston Children's Hospital. "We found that the beginning of cancer occurs after activation of an oncogene or loss of a tumor suppressor, and involves a change that takes a single cell back to a stem cell state."
3. Amyloidosis- mono or polyclonal?
4. The key paper is Pepys Lab 2015 that we interpret as follows " you can stick whatever you like on the amyloid but until igG1 ( 66% of human antibodies -wiki) is there in sufficient levels to trigger FBGC or MGC formation to engulf the amyloid fibrils, you can whistle Dixie. Evidence in favour of this proposition is Pepys amyloid phase 2 was slow until threshold of fully humanised monoclonal IgG1 SAP was introduced and then clearance happened in 14 days. 
5. Golombick et al curcumin retards paraprotein level but clearance is slow in agreement with 4 above assertion.
6. so we have 2 paths, 
1. deal with GlaxoSmith Kline or find an alternative supplier and write a patent
2. ld IgG1 levels internally and talk to JL nephew as to whether endogenous is good enough or an exogeneous material must be conditioned to SAP before introducing. 
3. internal may be possible via GH stimulation or other eg (1), (2), (3), (4), (5), (6), (7)
7. we go with X

Feb 2016 Protocol

1.  Re-hydrate for cell volume (Altland)
2. Neutral pH of saliva and urine ( Altland)
3. diet-
4. bibs and bobs foods  for heart etc, defib training
5. Assume Metabolic  trigger- 
6. Preferably stress with KD, and or eK
7. attack of poly-clonal family down to resistant monoclone hypothesis
8. fast- DCA, chemo CyBorD
9. slow curcumin, green tea
10. add nitro for angina due to precipitate in porosity and attachment of chlomcron fats reducing flow
11. Hi P Oxygen therapy
12. Endogenous or exogenous conditioned IgG1 
13. measure routinely ( monthly)